Asymmetric attrition and secondary chromosome destabilization after double-strand breaks in human embryonic development
Abstract DNA repair in human embryos is poorly understood, and double-strand breaks (DSBs) can cause chromosome loss. We show that chromosomal alterations relative to an induced DSB are asymmetric: acentric arms show complementary gains and losses, while centric arms are biased toward losses. Centro...
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| Autori principali: | , , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Portfolio
2026-06-01
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| Serie: | Nature Communications |
| Accesso online: | https://doi.org/10.1038/s41467-026-73891-7 |
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