Spectra without stories: reporting 94% dark and unidentified ancient proteomes [version 1; peer review: 2 approved, 1 approved with reservations]

Background Data-dependent, bottom-up proteomics is widely used for identifying proteins and peptides. However, one key challenge is that 70% of fragment ion spectra consistently fail to be assigned by conventional database searching. This ‘dark matter’ of bottom-up proteomics seems to affect fields...

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Үндсэн зохиолчид:	Frido Welker, Yun Chiang, Matthew James Collins
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	F1000 Research Ltd 2024-04-01
Цуврал:	Open Research Europe
Нөхцлүүд:	palaeoproteomics DDA shotgun proteomics database searching bioinformatics challenges eng
Онлайн хандалт:	https://open-research-europe.ec.europa.eu/articles/4-71/v1
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!