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Ac-225 radiochemistry through the lens of [225Ac]Ac-DOTA-TATE

Abstract Background Targeted alpha therapy with Ac-225 showed to be effective in treating metastatic cancers. However, the complex decay chain requires optimized radiolabeling and quality control. This study aims to determine critical parameters and establish optimal labeling and accurate measuring...

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Principais autores: Eline L. Hooijman, Jan R. de Jong, Carolline M. Ntihabose, Frank Bruchertseifer, Alfred Morgenstern, Yann Seimbille, Tessa Brabander, Stijn L. W. Koolen, Erik de Blois
Formato: Artigo
Idioma:Inglês
Publicado: SpringerOpen 2025-02-01
Series:EJNMMI Radiopharmacy and Chemistry
Assuntos:
Targeted alpha therapy (TAT)
Ac-225/Fr-221
Quality control
Radiopharmaceutical implementation
Radiochemical yield
Radiochemical purity
Acceso en liña:https://doi.org/10.1186/s41181-025-00332-z
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