Focused ultrasound enhances targeted curcumin delivery and alleviates behavioral and neuropathological deficits in a Parkinson’s disease mouse model

IntroductionCurcumin exhibits potent neuroprotective properties but is limited by poor blood-brain barrier (BBB) permeability. This study aimed to evaluate whether focused ultrasound (FUS)-mediated BBB opening enhances curcumin delivery and therapeutic efficacy in a 6-hydroxydopamine (6-OHDA) mouse...

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Autores principales:	Shu-Mei Yang, Sen-Hi Yeoh, Meng-Ting Lin, Ming-Yen Hsiao, Chueh-Hung Wu, Sung-Jan Lin, Wen-Shiang Chen
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2026-02-01
Colección:	Frontiers in Aging Neuroscience
Materias:	anti-inflammatory blood–brain barrier curcumin drug delivery focused ultrasound neuroprotection
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fnagi.2026.1740256/full
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