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ESPN activates ZEB1-mediated EMT through the PI3K/AKT/mTOR axis to promote osteosarcoma metastasis

Abstract Background Osteosarcoma (OS) is a primary bone malignancy characterized by early metastasis and generally poor prognosis. ESPN is highly expressed and plays an important role in regulating the aggressive phenotypes of several cancer cell types. However, little is known about the molecular m...

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Principais autores: Ruikai Zhou, Hongyu Wu, Hao You, Xiaofei Wang, Xiuchen Yuan, Zhengyi Sun, Dong Zhou, Yuqing Jiang, Yifei Shen
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-05-01
Serier:Journal of Translational Medicine
Fag:
ESPN
Epithelial-mesenchymal transition
mTOR
Osteosarcoma
Metastasis
Online adgang:https://doi.org/10.1186/s12967-025-06500-8
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