ESPN activates ZEB1-mediated EMT through the PI3K/AKT/mTOR axis to promote osteosarcoma metastasis

Abstract Background Osteosarcoma (OS) is a primary bone malignancy characterized by early metastasis and generally poor prognosis. ESPN is highly expressed and plays an important role in regulating the aggressive phenotypes of several cancer cell types. However, little is known about the molecular m...

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Hlavní autoři:	Ruikai Zhou, Hongyu Wu, Hao You, Xiaofei Wang, Xiuchen Yuan, Zhengyi Sun, Dong Zhou, Yuqing Jiang, Yifei Shen
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2025-05-01
Edice:	Journal of Translational Medicine
Témata:	ESPN Epithelial-mesenchymal transition mTOR Osteosarcoma Metastasis
On-line přístup:	https://doi.org/10.1186/s12967-025-06500-8
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