The Shank3Venus/Venus knock in mouse enables isoform-specific functional studies of Shank3a

BackgroundShank3 is a scaffolding protein essential for the organization and function of the glutamatergic postsynapse. Monogenic mutations in SHANK3 gene are among the leading genetic causes of Autism Spectrum Disorders (ASD). The multiplicity of Shank3 isoforms seems to generate as much functional...

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Hlavní autoři:	Nathalie Bouquier, Sophie Sakkaki, Fabrice Raynaud, Anne-Laure Hemonnot-Girard, Vincent Seube, Vincent Compan, Federica Bertaso, Julie Perroy, Enora Moutin
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2022-12-01
Edice:	Frontiers in Neuroscience
Témata:	Shank3 knock in ASD model isoform-specific tagging Shank3Δ⁢C Shank3a
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fnins.2022.1081010/full
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