The Neomycin Resistance Cassette in the Targeted Allele of Shank3B Knock-Out Mice Has Potential Off-Target Effects to Produce an Unusual Shank3 Isoform

Variants of the SH3 and multiple ankyrin repeat domains 3 (SHANK3), which encodes postsynaptic scaffolds, are associated with brain disorders. The targeted alleles in a few Shank3 knock-out (KO) lines contain a neomycin resistance (Neo) cassette, which may perturb the normal expression of neighborin...

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Autors principals:	Chunmei Jin, Hyojin Kang, Taesun Yoo, Jae Ryun Ryu, Ye-Eun Yoo, Ruiying Ma, Yinhua Zhang, Hyae Rim Kang, Yoonhee Kim, Hyunyoung Seong, Geul Bang, Sangwoo Park, Seok-Kyu Kwon, Woong Sun, Hyunkyung Kim, Jin Young Kim, Eunjoon Kim, Kihoon Han
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2021-01-01
Col·lecció:	Frontiers in Molecular Neuroscience
Matèries:	Shank3B knock-out Neo cassette gene expression off-target effect mouse chromosome 15
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fnmol.2020.614435/full
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