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Ehmt2 inactivation in pancreatic epithelial cells shapes the transcriptional landscape and inflammation response of the whole pancreas

Introduction: The Euchromatic Histone Methyl Transferase Protein 2 (EHMT2), also known as G9a, deposits transcriptionally repressive chromatin marks that play pivotal roles in the maturation and homeostasis of multiple organs. Recently, we have shown that Ehmt2 inactivation in the mouse pancreas alt...

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Principais autores: Gareth Pollin, Angela J. Mathison, Thiago M. de Assuncao, Anju Thomas, Atefeh Zeighami, Ann Salmonson, Hongfei Liu, Guillermo Urrutia, Pallavi Vankayala, Stephen J. Pandol, Johnny C. Hong, Michael T. Zimmermann, Juan Iovanna, Victor X. Jin, Raul Urrutia, Gwen Lomberk
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2024-06-01
coleção:Frontiers in Genetics
Assuntos:
EHMT2 (G9a)
acute pancreatitis
inflammation
epigenetics
gene expression
RNA-seq
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fgene.2024.1412767/full
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