KrasG12D induces changes in chromatin territories that differentially impact early nuclear reprogramming in pancreatic cells

Abstract Background Pancreatic ductal adenocarcinoma initiation is most frequently caused by Kras mutations. Results Here, we apply biological, biochemical, and network biology methods to validate GEMM-derived cell models using inducible KrasG12D expression. We describe the time-dependent, chromatin...

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Bibliografiske detaljer

Principais autores:	Angela J. Mathison, Romica Kerketta, Thiago Milech de Assuncao, Elise Leverence, Atefeh Zeighami, Guillermo Urrutia, Timothy J. Stodola, Marina Pasca di Magliano, Juan L. Iovanna, Michael T. Zimmermann, Gwen Lomberk, Raul Urrutia
Format:	Artigo
Sprog:	Inglês
Udgivet:	BMC 2021-10-01
Serier:	Genome Biology
Fag:	Pancreatic cancer KRAS Epigenomics
Online adgang:	https://doi.org/10.1186/s13059-021-02498-6
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