Hypoxia-inducible factors (HIFs) and phosphorylation: Impact on stability, localization and transactivity

The hypoxia-inducible factor alpha-subnits (HIFs) are key transcription factors in the mammalian response to oxygen deficiency. The HIF-alpha regulation in response to hypoxia occurs primarily on the level of protein stability due to posttranslational hydroxylation and proteasomal degradation. Howev...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Thomas eKietzmann, Daniela eMennerich, Elitsa Y. eDimova
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Frontiers Media S.A. 2016-02-01
Σειρά:	Frontiers in Cell and Developmental Biology
Θέματα:	Phosphorylation hypoxia kinase HIF-1α MAPK pathway PI3K/PKB pathway
Διαθέσιμο Online:	http://journal.frontiersin.org/Journal/10.3389/fcell.2016.00011/full
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