Insulin-Sensitizing Effect of LXR Agonist T0901317 in High-Fat Fed Rats is Associated with Restored Muscle GLUT4 Expression and Insulin-Stimulated AS160 Phosphorylation

Background/Aim: Liver X receptors (LXRs) are ligand-activated transcription factors that were shown to stimulate hepatic lipogenesis leading to liver steatosis and hypertriglyceridemia. Despite their pro-lipogenic action, LXR activators normalize glycemia and improve insulin sensitivity in rodent mo...

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Detalhes bibliográficos

Principais autores:	Marcin Baranowski, Piotr Zabielski, Agnieszka U. Błachnio-Zabielska, Ewa Harasim, Adrian Chabowski, Jan Górski
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Cell Physiol Biochem Press GmbH & Co KG 2014-04-01
Colecção:	Cellular Physiology and Biochemistry
Assuntos:	Akt/PKB Insulin resistance IRS1 Lipid mediators Skeletal muscle
Acesso em linha:	http://www.karger.com/Article/FullText/358675
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