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Improvement of Motor Nerve Conduction Velocity in Diabetic Rats Requires Normalization of the Polyol Pathway Metabolites Flux

Using ranirestat, an aldose reductase (AR) inhibitor, we investigated the relationship between sorbitol and fructose levels in the sciatic nerve and motor nerve conduction velocity (MNCV) in streptozotocin (STZ)-treated diabetic rats. Ranirestat inhibited rat and recombinant human AR with similar IC...

Бүрэн тодорхойлолт

-д хадгалсан:
Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид: Takafumi Matsumoto, Yoshiyuki Ono, Masuo Kurono, Akemi Kuromiya, Keiji Nakamura, Vera Bril
Формат: Artigo
Хэл сонгох:Inglês
Хэвлэсэн: Elsevier 2009-01-01
Цуврал:Journal of Pharmacological Sciences
Онлайн хандалт:http://www.sciencedirect.com/science/article/pii/S1347861319312757
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