Circadian rhythm disruption-mediated downregulation of Bmal1 exacerbates DSS-induced colitis by impairing intestinal barrier

BackgroundCircadian rhythm disruption (CRD) is thought to increase the risk of inflammatory bowel disease. The deletion of Bmal1, a core transcription factor, leads to a complete loss of the circadian rhythm and exacerbates the severity of dextran sodium sulfate (DSS)-induced colitis in mice. Howeve...

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Bibliografske podrobnosti

Principais autores:	Zhongchao Zhang, Wanneng Li, Xu Han, Dean Tian, Wei Yan, Mei Liu, Li Cao
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2024-06-01
Serija:	Frontiers in Immunology
Teme:	ulcerative colitis Bmal1 apoptosis intestinal barrier autophagy
Online dostop:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1402395/full
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