Evaluation of Relationship of the Methylene Tetrahydrofolate Reductase Enzyme Polymorphisms with Serum Methotrexate Concentration and Toxicity in Acute Lymphoblastic Leukemia Patients Treated with High Dose Methotrexate Infusion

Background: Methotrexate (MTX) blocks Methylene Tetrahydrofolate Reductase (MTHFR) Enzyme thereby, interrupt folate metabolism, it is used in the treatment of cancer and autoimmune disorders. Aim and Objectives: The present study aimed to evaluate the relationship of the MTHFR polymorphisms wit...

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Hlavní autoři:	Manjusha Sajith, Atmaram Pawar, Abdulrahaman A. Momin, Vibha Bafna, Sandeep Bartakke, Kannan Subramaniyan
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Krishna Vishwa Vidyapeeth (Deemed to be University), Karad 2020-07-01
Edice:	Journal of Krishna Institute of Medical Sciences University
Témata:	methylene tetrahydrofolate reductase enzyme polymorphism methotrexate acute lymphoblastic leukemia
On-line přístup:	https://www.jkimsu.com/jkimsu-vol9no3/JKIMSU,%20Vol.%209,%20No.%203,%20July-September%202020%20Page%2027-39.pdf
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