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TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis

A cellular protease, SPP, participates in production of the mature core protein of hepatitis C virus (HCV). Here, the authors show in mouse models that SPP inhibition reduces viral propagation and pathogenesis via proteasomal degradation of the immature core protein mediated by the E3 ubiquitin liga...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Sayaka Aizawa, Toru Okamoto, Yukari Sugiyama, Takahisa Kouwaki, Ayano Ito, Tatsuya Suzuki, Chikako Ono, Takasuke Fukuhara, Masahiro Yamamoto, Masayasu Okochi, Nobuhiko Hiraga, Michio Imamura, Kazuaki Chayama, Ryosuke Suzuki, Ikuo Shoji, Kohji Moriishi, Kyoji Moriya, Kazuhiko Koike, Yoshiharu Matsuura
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Nature Portfolio 2016-05-01
Rangatū:Nature Communications
Urunga tuihono:https://doi.org/10.1038/ncomms11379
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