TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis

A cellular protease, SPP, participates in production of the mature core protein of hepatitis C virus (HCV). Here, the authors show in mouse models that SPP inhibition reduces viral propagation and pathogenesis via proteasomal degradation of the immature core protein mediated by the E3 ubiquitin liga...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Sayaka Aizawa, Toru Okamoto, Yukari Sugiyama, Takahisa Kouwaki, Ayano Ito, Tatsuya Suzuki, Chikako Ono, Takasuke Fukuhara, Masahiro Yamamoto, Masayasu Okochi, Nobuhiko Hiraga, Michio Imamura, Kazuaki Chayama, Ryosuke Suzuki, Ikuo Shoji, Kohji Moriishi, Kyoji Moriya, Kazuhiko Koike, Yoshiharu Matsuura
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2016-05-01
Edice:	Nature Communications
On-line přístup:	https://doi.org/10.1038/ncomms11379
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!