Celastrol inhibits lung infiltration in differential syndrome animal models by reducing TNF-α and ICAM-1 levels while preserving differentiation in ATRA-induced acute promyelocytic leukemia cells.

All-trans retinoic acid (ATRA) is a revolutionary agent for acute promyelocytic leukemia (APL) treatment via differentiation induction. However, ATRA treatment also increases cytokine, chemokine, and adhesive molecule (mainly ICAM-1) expression, which can cause clinical complications, including a se...

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Autors principals:	Li-min Xu, Yue-juan Zheng, Ying Wang, Yang Yang, Fan-fan Cao, Bin Peng, Xiong-fei Xu, Hua-zhang An, Ao-xiang Zheng, Deng-hai Zhang, Georges Uzan, Yi-zhi Yu
Format:	Artigo
Idioma:	Inglês
Publicat:	Public Library of Science (PLoS) 2014-01-01
Col·lecció:	PLoS ONE
Accés en línia:	http://europepmc.org/articles/PMC4130635?pdf=render
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