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Mutational dissection of HCMV gB and gH cytoplasmic tails highlights conserved and divergent features of fusion regulation

ABSTRACT In herpesviruses, the fusogenic activity of the conserved glycoproteins gB and gH is regulated by their cytoplasmic (or intraviral) tails. However, prior to this work, their regulatory mechanisms had only been investigated in Alpha- and Gamma- but not in Betaherpesvirinae. Here, we develope...

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Detalhes bibliográficos
Principais autores: Chanyoung Lee, Hannah K. DiBella, Ekaterina E. Heldwein
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2025-11-01
coleção:mBio
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Acesso em linha:https://journals.asm.org/doi/10.1128/mbio.01905-25
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