Spi1 R235C point mutation confers hypersensitivity to radiation-induced acute myeloid leukemia in mice

Summary: Ionizing radiation (IR) is a risk factor for acute myeloid leukemia (rAML). Murine rAMLs feature both hemizygous chromosome 2 deletions (Del2) and point mutations (R235) within the hematopoietic regulatory gene Spi1. We generated a heterozygous CBA Spi1 R235 mouse (CBASpm/+) which develops...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Natalie Brown, Rosemary Finnon, Paul Finnon, Roisin McCarron, Lourdes Cruz-Garcia, Grainne O’Brien, Eleanor Herbert, Cheryl L. Scudamore, Edouard Morel, Christophe Badie
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2023-09-01
Schriftenreihe:	iScience
Schlagworte:	Cancer Genetics Molecular Genetics
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2589004223016073
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!