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TKI resistance related genes in LUAD predict patient prognosis and tumor immune microenvironment with LHX2 as a hub gene

Abstract Background Non-small cell lung cancer (NSCLC), particularly lung adenocarcinoma (LUAD), is a leading cause of cancer-related mortality. Osimertinib, a third-generation epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI), improves survival, but acquired resistance remains a...

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Principais autores: Ruohan Huang, Qi Liang, Hongya Wang, Huizhu Qian, Renhua Guo
Format: Artigo
Sprog:Inglês
Udgivet: Springer 2025-11-01
Serier:Discover Oncology
Fag:
NSCLC
Osimertinib
Drug resistance
LHX2
Prognosis productive model
Online adgang:https://doi.org/10.1007/s12672-025-03959-1
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