Differential effects of fetal bovine serum and human platelet lysate on mesenchymal stromal cell-mediated support of hematopoietic stem/progenitor cells: a functional and transcriptomic analysis

Abstract Background Umbilical cord blood (UCB) is a valuable source of hematopoietic stem and progenitor cells (HSPC) for transplantation. However, limited cell numbers require ex vivo expansion for effective treatment of adult patients. Mesenchymal stromal cell (MSC)-based co-cultures offer a suppo...

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Principais autores:	Maria Catarina Carreira, André Branco, Miguel Casanova, Carolina Smet, Cláudia L. da Silva, Ana Fernandes-Platzgummer
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	BMC 2025-11-01
סדרה:	Stem Cell Research & Therapy
נושאים:	Umbilical cord blood Hematopoietic stem/progenitor cells Ex vivo expansion Co-culture Mesenchymal stromal cells Human platelet lysate
גישה מקוונת:	https://doi.org/10.1186/s13287-025-04835-z
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