Transcriptomic analysis to uncover the mechanism of radiosensitization of AR-positive triple-negative breast cancers with AR inhibition

Abstract The androgen receptor (AR) has been identified as a driver of tumor growth and radioresistance in triple-negative breast cancers (TNBC), though the mechanistic role of AR in response to radiation therapy (RT) remains unknown. Here, we demonstrate that inhibition with the second-generation a...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Breanna McBean, Benjamin Hauk, Anna R. Michmerhuizen, Benjamin C. Chandler, Andrea M. Pesch, Lynn M. Lerner, Douglas Gurdak, Connor Ward, Priyanka Rana, Reine Abou Zeidane, Vesna Mercer, Mingfang Tao, Ethan Hochmuth, Kassidy M. Jungles, Stephanie The, Meilan Liu, Daniel E. Spratt, Alan P. Boyle, Lori J. Pierce, Corey W. Speers
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Nature Portfolio 2026-02-01
Sarja:	npj Breast Cancer
Linkit:	https://doi.org/10.1038/s41523-026-00916-1
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