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Oligodendrogenesis and myelination tracing in a CRISPR/Cas9-engineered brain microphysiological system

IntroductionOligodendrocytes (OLs) are the myelin-forming cells of the central nervous system (CNS). Although OLs can be differentiated from human-induced pluripotent stem cells (hiPSCs), the in vitro modeling of axon myelination in human cells remains challenging. Brain microphysiological systems (...

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Principais autores: July Carolina Romero, Cynthia Berlinicke, Sharon Chow, Yukan Duan, Yifei Wang, Xitiz Chamling, Lena Smirnova
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2023-01-01
coleção:Frontiers in Cellular Neuroscience
Assuntos:
brain organoids
CRISPR/Cas9
hiPSC fusion KI line
neurodevelopment
oligodendrogenesis
myelination
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fncel.2022.1094291/full
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