Implications of differential peroxyl radical-induced inactivation of glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase for the pentose phosphate pathway

Abstract Escherichia coli glucose-6-phosphate dehydrogenase (G6PDH) and 6-phosphogluconate dehydrogenase (6PGDH) are key enzymes of the pentose phosphate pathway, responsible for the NADPH production in cells. We investigated modification of both enzymes mediated by peroxyl radicals (ROO·) to determ...

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Hlavní autoři:	Juan Sebastián Reyes, Eduardo Fuentes-Lemus, Juan David Figueroa, Javier Rojas, Angélica Fierro, Felipe Arenas, Per M. Hägglund, Michael J. Davies, Camilo López-Alarcón
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2022-12-01
Edice:	Scientific Reports
On-line přístup:	https://doi.org/10.1038/s41598-022-25474-x
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