Blockade of 6-phosphogluconate dehydrogenase generates CD8+ effector T cells with enhanced anti-tumor function

Summary: Although T cell expansion depends on glycolysis, T effector cell differentiation requires signaling via the production of reactive oxygen species (ROS). Because the pentose phosphate pathway (PPP) regulates ROS by generating nicotinamide adenine dinucleotide phosphate (NADPH), we examined h...

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Autori principali:	Saeed Daneshmandi, Teresa Cassel, Penghui Lin, Richard M. Higashi, Gerburg M. Wulf, Vassiliki A. Boussiotis, Teresa W.-M. Fan, Pankaj Seth
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2021-03-01
Serie:	Cell Reports
Soggetti:	6PGD pentose phosphate pathway effector T cells metabolism reactive oxygen species tumor immunotherapy
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2211124721001455
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