Proton pump inhibitor alters Th17/Treg balance and induces gut dysbiosis suppressing contact hypersensitivity reaction in mice

Proton pump inhibitors (PPIs), such as omeprazole, are the most commonly prescribed drugs. Treatment with PPIs alters gut microbiota composition and reduces the production of reactive oxygen (ROS) and proinflammatory IL-1β, IL-6, and TNF-α cytokines. Here, using the T cell-dependent contact hypersen...

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Principais autores:	Anna Strzępa, Katarzyna Marcińska, Aneta Kiecka, Monika Majewska-Szczepanik, Marian Szczepanik
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2024-08-01
coleção:	Frontiers in Immunology
Assuntos:	proton pump inhibitors omeprazole contact hypersensitivity gut microbiota dysbiosis immunomodulation
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1390025/full
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