Delineating the stepwise millisecond allosteric activation mechanism of the class C GPCR dimer mGlu5

Abstract Two-thirds of signaling hormones and one-third of approved drugs exert their effects by binding and modulating the G protein-coupled receptors (GPCRs) activation. While the activation mechanism for monomeric GPCRs has been well-established, little is known about GPCRs in dimeric form. Here,...

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Hlavní autoři:	Mingyu Li, Xiaobing Lan, Xinchao Shi, Chunhao Zhu, Xun Lu, Jun Pu, Shaoyong Lu, Jian Zhang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2024-08-01
Edice:	Nature Communications
On-line přístup:	https://doi.org/10.1038/s41467-024-51999-y
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