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Cord blood T regulatory cells synergize with ruxolitinib to improve GVHD outcomes

BackgroundAdoptive therapy with umbilical cord blood (UCB) T-regulatory (Treg) cells can prevent graft vs. host disease (GVHD). We hypothesize that UCB Tregs can treat GVHD and synergize with ruxolitinib, Jak2 inhibitor, to improve outcomes.MethodsUCB Treg potency and efficacy was examined using cel...

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Principais autores: Ke Zeng, Hongbing Ma, Meixian Huang, Mi-Ae Lyu, Tara Sadeghi, Christopher R. Flowers, Simrit Parmar
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2024-12-01
Serier:Frontiers in Transplantation
Fag:
GVHD
T regulatory cell
allogeneic
cord blood
ruxolitinib
Online adgang:https://www.frontiersin.org/articles/10.3389/frtra.2024.1448650/full
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