Sphingosylphosphorylcholine acts in an anti-inflammatory manner in renal mesangial cells by reducing interleukin-1β-induced prostaglandin E2 formation

Sphingosylphosphorylcholine (SPC) is a bioactive lipid that binds to G protein-coupled-receptors and activates various signaling cascades. Here, we show that in renal mesangial cells, SPC not only activates various protein kinase cascades but also activates Smad proteins, which are classical members...

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Detalles Bibliográficos

Autores principales:	Cuiyan Xin, Shuyu Ren, Wolfgang Eberhardt, Josef Pfeilschifter, Andrea Huwiler
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2007-09-01
Colección:	Journal of Lipid Research
Materias:	transforming growth factor-β2 Smad secretory phospholipase A2 connective tissue growth factor
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S0022227520424861
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