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Bioadhesive hybrid system of niosomes and pH sensitive in situ gel for itraconazole ocular delivery: Dual approach for efficient treatment of fungal infections

Itraconazole (ITZ) is a highly effective antifungal agent. However, its oral application is associated with systemic toxicity and poor topical use. The present study aims to improve the antifungal activity of ITZ by loading it into bioadhesive niosomes. This approach is considered to enhance the ocu...

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Principais autores: Mohamed M. Badran, Areej Alsubaie, Mounir M. Salem Bekhit, Abdullah H. Alomrani, Aliyah Almomen, Mohamed Abbas Ibrahim, Doaa Hasan Alshora
Format: Artigo
Sprog:Inglês
Udgivet: Springer 2024-12-01
Serier:Saudi Pharmaceutical Journal
Fag:
Itraconazole
Niosomes
Bioadhesive
In situ gel
Ocular delivery
Antifungal activity
Online adgang:http://www.sciencedirect.com/science/article/pii/S1319016424002597
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