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Small Molecule Liver X Receptor Modulator GAC0001E5 Targets Mechanisms of Endocrine Resistance in Estrogen Receptor-Positive Breast Cancer Cells

Endocrine therapy is an effective and common treatment strategy for estrogen receptor (ER)-positive breast cancers. However, the development of endocrine resistance, through genetic mutations and epigenetic alterations, in about 40% of treated patients remains a significant therapeutic challenge. Li...

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Main Authors: Shinjini Basu, Asitha Premaratne, Scott Widmann, Esther A. Olaleye, Chin-Yo Lin
Format: Artigo
Language:Inglês
Published: MDPI AG 2026-06-01
Series:Biomolecules
Subjects:
breast cancer
liver X receptor
estrogen receptor
endocrine resistance
Online Access:https://www.mdpi.com/2218-273X/16/6/856
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