Consecutive Four-Component Coupling-Addition Aza-Anellation <i>Pictet</i>–<i>Spengler</i> Synthesis of Tetrahydro-<i>β</i>-Carbolines: An Optimized <i>Michael</i> Addition and Computational Study on the Aza-Anellation Step

Starting from acid chlorides, alkynes, tryptamines, and acryloyl chloride, 21 densely substituted tetrahydro-<i>β</i>-carbolines were prepared in a four-component, one-pot reaction. In this study, the aza-<i>Michael</i> addition step to generate intermediate enaminones was optimized in the presence...

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Auteurs principaux:	Kai Ries, Françoise A. Aouane, Thomas J. J. Müller
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2023-06-01
Collection:	Organics
Sujets:	aza-<i>Michael</i> addition tetrahydro-<i>β</i>-carbolines catalysis one-pot reaction multicomponent reaction ytterbium (III) triflate
Accès en ligne:	https://www.mdpi.com/2673-401X/4/3/25
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