Tuning dCas9's ability to block transcription enables robust, noiseless knockdown of bacterial genes
Abstract Over the past few years, tools that make use of the Cas9 nuclease have led to many breakthroughs, including in the control of gene expression. The catalytically dead variant of Cas9 known as dCas9 can be guided by small RNAs to block transcription of target genes, in a strategy also known a...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Springer Nature
2018-03-01
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| Schriftenreihe: | Molecular Systems Biology |
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| Online-Zugang: | https://doi.org/10.15252/msb.20177899 |
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