The Sigma 2 receptor promotes and the Sigma 1 receptor inhibits mu-opioid receptor-mediated antinociception

Abstract The Sigma-1 receptor (σ1R) has emerged as an interesting pharmacological target because it inhibits analgesia mediated by mu-opioid receptors (MOR), and also facilitates the development of neuropathic pain. Based on these findings, the recent cloning of the Sigma-2 receptor (σ2R) led us to...

Description complète

Détails bibliographiques

Auteurs principaux:	Pilar Sánchez-Blázquez, Elsa Cortés-Montero, María Rodríguez-Muñoz, Manuel Merlos, Javier Garzón-Niño
Format:	Artigo
Langue:	Inglês
Publié:	BMC 2020-11-01
Collection:	Molecular Brain
Sujets:	Sigma 2 receptor Sigma 1 receptor Knockout mice Mu opioid receptor Neuropathic pain Analgesia
Accès en ligne:	http://link.springer.com/article/10.1186/s13041-020-00676-4
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!