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Atomic mutagenesis in ion channels with engineered stoichiometry

C-type inactivation of potassium channels fine-tunes the electrical signaling in excitable cells through an internal timing mechanism that is mediated by a hydrogen bond network in the channels' selectively filter. Previously, we used nonsense suppression to highlight the role of the conserved Trp43...

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Autori principali: John D Lueck, Adam L Mackey, Daniel T Infield, Jason D Galpin, Jing Li, Benoît Roux, Christopher A Ahern
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications Ltd 2016-10-01
Serie:eLife
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Accesso online:https://elifesciences.org/articles/18976
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