Evaluating miRNA Sequencing and Integrative Proteomics for Identifying Plasma miRNAs as Potential Pharmacodynamic Biomarkers of IFNβ‐1a Biologics

ABSTRACT We used miRNA sequencing to identify candidate plasma pharmacodynamic (PD) biomarkers of interferon beta‐1a (IFNβ‐1a) biologics and explored miRNA‐mRNA targeted protein relationships and networks to support identified miRNA candidates. Plasma samples from 36 healthy subjects from a placebo‐...

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Prif Awduron:	Mai Mehanna, Lakshmi Manasa Chekka, Barry A. Rosenzweig, Deepti P. Samarth, Esraa G. Mohamed, Isaac Raplee, Catherine Sullenberger, Erica Decker, Sarah J. Schrieber, Yow‐Ming Wang, Jeffry Florian, Paula L. Hyland
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Wiley 2025-12-01
Cyfres:	Clinical and Translational Science
Pynciau:	interferon beta‐1a microRNAs (miRNAs) pharmacodynamic biomarkers
Mynediad Ar-lein:	https://doi.org/10.1111/cts.70444
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