Evaluating miRNA Sequencing and Integrative Proteomics for Identifying Plasma miRNAs as Potential Pharmacodynamic Biomarkers of IFNβ‐1a Biologics

ABSTRACT We used miRNA sequencing to identify candidate plasma pharmacodynamic (PD) biomarkers of interferon beta‐1a (IFNβ‐1a) biologics and explored miRNA‐mRNA targeted protein relationships and networks to support identified miRNA candidates. Plasma samples from 36 healthy subjects from a placebo‐...

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Principais autores:	Mai Mehanna, Lakshmi Manasa Chekka, Barry A. Rosenzweig, Deepti P. Samarth, Esraa G. Mohamed, Isaac Raplee, Catherine Sullenberger, Erica Decker, Sarah J. Schrieber, Yow‐Ming Wang, Jeffry Florian, Paula L. Hyland
Formato:	Artigo
Idioma:	Inglês
Publicado:	Wiley 2025-12-01
Series:	Clinical and Translational Science
Assuntos:	interferon beta‐1a microRNAs (miRNAs) pharmacodynamic biomarkers
Acceso en liña:	https://doi.org/10.1111/cts.70444
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