Searching for protein variants with desired properties using deep generative models

Abstract Background Protein engineering aims to improve the functional properties of existing proteins to meet people’s needs. Current deep learning-based models have captured evolutionary, functional, and biochemical features contained in amino acid sequences. However, the existing generative model...

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Bibliografski detalji

Glavni autori:	Yan Li, Yinying Yao, Yu Xia, Mingjing Tang
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2023-07-01
Serija:	BMC Bioinformatics
Teme:	Protein engineering Temporal convolutional network Deep generative model Variational autoencoder
Online pristup:	https://doi.org/10.1186/s12859-023-05415-9
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