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In vitro reconstitution reveals major differences between human and bacterial cytochrome c synthases

Cytochromes c are ubiquitous heme proteins in mitochondria and bacteria, all possessing a CXXCH (CysXxxXxxCysHis) motif with covalently attached heme. We describe the first in vitro reconstitution of cytochrome c biogenesis using purified mitochondrial (HCCS) and bacterial (CcsBA) cytochrome c synth...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Molly C Sutherland, Deanna L Mendez, Shalon E Babbitt, Dustin E Tillman, Olga Melnikov, Nathan L Tran, Noah T Prizant, Andrea L Collier, Robert G Kranz
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications Ltd 2021-05-01
Schriftenreihe:eLife
Schlagworte:
Heme
cytochrome c
synthases
heme attachment
cytochrome c biogenesis
post translational modification
Online-Zugang:https://elifesciences.org/articles/64891
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