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A multimodal biological margin risk index predicts recurrence after neoadjuvant immunochemotherapy in head and neck squamous cell carcinoma

BackgroundConventional classification of surgical margins is inadequate for head and neck squamous cell carcinoma (HNSCC) treated with neoadjuvant immunochemotherapy (NICT), as it fails to capture the complex biological changes in the tumor microenvironment. This study aimed to develop a novel defin...

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Principais autores: Ning Xu, Defeng Chen, Junui Yuan, Tao Huang, Xu Zhang, Qigen Fang, Wenlu Li
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-02-01
coleção:Frontiers in Immunology
Assuntos:
head and neck squamous cell carcinoma
immunotherapy
neoadjuvant therapy
prognosis
surgical margin
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1740643/full
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