Polygenic score modifies risk for Alzheimer's disease in APOE ε4 homozygotes at phenotypic extremes
Abstract Introduction Diversity in cognition among apolipoprotein E (APOE) ε4 homozygotes can range from early‐onset Alzheimer's disease (AD) to a lifetime with no symptoms. Methods We evaluated a phenotypic extreme polygenic risk score (PRS) for AD between cognitively healthy APOE ε4 homozygotes ag...
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| Автори: | , , , , , , , , , , , , , , , , |
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| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
Wiley
2021-01-01
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| Серія: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| Предмети: | |
| Онлайн доступ: | https://doi.org/10.1002/dad2.12226 |
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