Polygenic score modifies risk for Alzheimer's disease in APOE ε4 homozygotes at phenotypic extremes

Abstract Introduction Diversity in cognition among apolipoprotein E (APOE) ε4 homozygotes can range from early‐onset Alzheimer's disease (AD) to a lifetime with no symptoms. Methods We evaluated a phenotypic extreme polygenic risk score (PRS) for AD between cognitively healthy APOE ε4 homozygotes ag...

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Bibliografiske detaljer

Principais autores:	Aamira J. Huq, Brian Fulton‐Howard, Moeen Riaz, Simon Laws, Robert Sebra, Joanne Ryan, Alzheimer's Disease Genetics Consortium, Alan E. Renton, Alison M. Goate, Colin L. Masters, Elsdon Storey, Raj C. Shah, Anne Murray, John McNeil, Ingrid Winship, Paul A. James, Paul Lacaze
Format:	Artigo
Sprog:	Inglês
Udgivet:	Wiley 2021-01-01
Serier:	Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
Fag:	Alzheimer's disease Alzheimer's disease dementia apolipoprotein E dementia resilience genetic modifiers polygenic risk score
Online adgang:	https://doi.org/10.1002/dad2.12226
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