The Adr1 transcription factor directs regulation of the ergosterol pathway and azole resistance in Candida albicans

ABSTRACT Transcription factors (TFs) play key roles in cellular regulation and are critical in the control of drug resistance in the fungal pathogen Candida albicans. We found that activation of the transcription factor C4_02500C_A (Adr1) conferred significant resistance against fluconazole. In Sacc...

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Autori principali:	Manjari Shrivastava, Gaëlle S. Kouyoumdjian, Eftyhios Kirbizakis, Daniel Ruiz, Manon Henry, Antony T. Vincent, Adnane Sellam, Malcolm Whiteway
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology 2023-10-01
Serie:	mBio
Soggetti:	rewiring Adr1 ergosterol Candida albicans alcohol and fatty acid metabolism
Accesso online:	https://journals.asm.org/doi/10.1128/mbio.01807-23
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