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Molecular mechanisms of thiazide-like diuretics-mediated inhibition of the human Na-Cl cotransporter

Abstract Thiazide-type and thiazide-like diuretics are structurally distinct first-line antihypertensive drugs that target the sodium-chloride cotransporter (NCC) in the kidney. Thiazide-like diuretics are reported to have better cardioprotective effects than thiazide-type diuretics, but whether thi...

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Autores principales: Chien-Ling Lee, Jianxiu Zhang, Liang Feng
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Portfolio 2025-08-01
Colección:Nature Communications
Acceso en línea:https://doi.org/10.1038/s41467-025-62714-w
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