Ibrutinib directly reduces CD8+T cell exhaustion independent of BTK

IntroductionCytotoxic CD8+ T cell (CTL) exhaustion is a dysfunctional state of T cells triggered by persistent antigen stimulation, with the characteristics of increased inhibitory receptors, impaired cytokine production and a distinct transcriptional profile. Evidence from immune checkpoint blockad...

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Bibliografiska uppgifter

Huvudupphov:	Ling Li, Manzhi Zhao, Caoimhe H. Kiernan, Melisa D. Castro Eiro, Marjan van Meurs, Inge Brouwers-Haspels, Merel E. P. Wilmsen, Dwin G. B. Grashof, Harmen J. G. van de Werken, Rudi W. Hendriks, Yvonne M. Mueller, Peter D. Katsikis
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Frontiers Media S.A. 2023-09-01
Serie:	Frontiers in Immunology
Ämnen:	immune checkpoint blockade T-cell exhaustion ibrutinib BTK inhibitor CD8+ T cells
Länkar:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1201415/full
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