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Design, Synthesis, and Computational Insights into PKMYT1 Inhibitors for the Treatment of Breast Cancer

<b>Background</b>: Membrane-associated tyrosine-threonine protein kinase 1 (PKMYT1), which is identified as a synthetic lethal partner of <i>CCNE1</i>, emerged as a promising therapeutic target in oncology. <b>Methods</b>: A series of novel PKMYT1 inhibitors were designed by employing a pharmacophor...

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Principais autores: Jinyu Yu, Haoyu Zhang, Chuanxu Su, Shizhe Yuan, Nian Liu, Yin Sun, Yixiang Sun, Zixuan Gao, Dongmei Zhao, Maosheng Cheng
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2025-08-01
coleção:Biomedicines
Assuntos:
CADD
PKMYT1 inhibitors
synthetic lethal
Acesso em linha:https://www.mdpi.com/2227-9059/13/9/2116
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