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Hypoxia promotes tumor immune evasion by suppressing MHC-I expression and antigen presentation

Abstract Hypoxia is a common feature of solid tumors that has previously been linked to resistance to radiotherapy and chemotherapy, and more recently to immunotherapy. In particular, hypoxic tumors exclude T cells and inhibit their activity, suggesting that tumor cells acquire a mechanism to evade...

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Hlavní autoři: Hala Estephan, Arun Tailor, Robert Parker, McKenzie Kreamer, Ioanna Papandreou, Leticia Campo, Alistair Easton, Eui Jung Moon, Nicholas C Denko, Nicola Ternette, Ester M Hammond, Amato J Giaccia
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Nature 2025-01-01
Edice:The EMBO Journal
Témata:
Hypoxia
MHC I Expression
Antigen Presentation
Autophagy
Immune Response
On-line přístup:https://doi.org/10.1038/s44318-024-00319-7
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