Hypoxia promotes tumor immune evasion by suppressing MHC-I expression and antigen presentation

Abstract Hypoxia is a common feature of solid tumors that has previously been linked to resistance to radiotherapy and chemotherapy, and more recently to immunotherapy. In particular, hypoxic tumors exclude T cells and inhibit their activity, suggesting that tumor cells acquire a mechanism to evade...

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Bibliografiska uppgifter

Huvudupphov:	Hala Estephan, Arun Tailor, Robert Parker, McKenzie Kreamer, Ioanna Papandreou, Leticia Campo, Alistair Easton, Eui Jung Moon, Nicholas C Denko, Nicola Ternette, Ester M Hammond, Amato J Giaccia
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Springer Nature 2025-01-01
Serie:	The EMBO Journal
Ämnen:	Hypoxia MHC I Expression Antigen Presentation Autophagy Immune Response
Länkar:	https://doi.org/10.1038/s44318-024-00319-7
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