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NEO212 induces mitochondrial apoptosis and impairs autophagy flux in ovarian cancer

Abstract Background Temozolomide-perillyl alcohol conjugate (NEO212), a novel temozolomide (TMZ) analog, was previously reported to exert its anti-cancer effect in non-small cell lung cancer (NSCLC), and human nasopharyngeal carcinoma (NPC), etc.. In the current study, we intend to illuminate the po...

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Principais autores: Xingguo Song, Lisheng Liu, Minghui Chang, Xinran Geng, Xingwu Wang, Weijun Wang, Thomas C. Chen, Li Xie, Xianrang Song
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-06-01
coleção:Journal of Experimental & Clinical Cancer Research
Assuntos:
NEO212
Mitochondrial apoptosis
Autophagic flux
TFEB
Ovarian cancer
Acesso em linha:http://link.springer.com/article/10.1186/s13046-019-1249-1
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